French ingredient manufacturer Silab has introduced Metallomia, a detoxifying active ingredient developed for menopausal skin. The launch focuses on ferritinophagy, a process that regulates the controlled release of iron for cellular needs. Silab says its modeling work on menopausal skin identified a deficiency in this process, connecting altered iron handling with premature skin aging.
According to the company, reduced ferritinophagy during menopause limits bioavailable iron and contributes to what it calls metallo-aging. UV exposure can intensify the problem: Silab says UV radiation promotes degradation of iron/ferritin complexes, causing a large, uncontrolled release of iron and significant oxidative stress. Metallomia is designed to relaunch ferritinophagy in menopausal skin, supporting iron delivery and helping restore key epidermal functions. By reducing iron/ferritin complexes, the ingredient is also intended to limit oxidative stress when skin is exposed to UV.
Company-reported volunteer outcomes
Silab reports that the targeted mechanism substantially reduces metallo-aging. In Caucasian volunteers, skin was described as revitalized from 14 days, with a reinforced skin barrier and a more unified, radiant complexion. In Asian volunteers, pigment spots were significantly reduced after 28 days, according to the company. Silab also reports that when Caucasian volunteers applied the ingredient before UV exposure, it prevented lipid peroxidation and limited the appearance of redness within hours after exposure. These outcomes are presented as company findings; the input does not provide full study protocols, sample sizes or independent verification.
Marshmallow root and a traced supply chain
For Metallomia’s development, Silab examined the molecular composition of marshmallow roots, which are particularly rich in mucilages. The company established a traced supply chain with French partners. It says the supply has been validated against criteria in the European Pharmacopoeia and authenticated through DNA barcoding. To make use of the roots’ mucilage content, Silab developed a specific enzyme-engineering process to extract polyuronides.
Formulation and positioning
Metallomia is a patented active ingredient recommended for all care products intended for menopausal skin at 0.5% to 2%. It is supplied as an aqueous solution and is described as easy to formulate. Silab says the ingredient complies with biodiversity regulations and has a natural-origin content of 100% under ISO 16128. It also complies with international cosmetics regulations in markets including Europe, the United States, China and Japan.
The launch adds a menopause-focused detoxification claim to Silab’s portfolio, with iron handling positioned as a specific pathway rather than a general antioxidant approach. The available information covers the proposed mechanism, company-reported volunteer results, raw-material sourcing and formulation guidance; broader independent evidence and detailed trial data are not included in the source material.